Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process
DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways.Efficient corrections of these DNA lesions are critical for maintaining genome integrity and prev